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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1A All Species: 6.36
Human Site: S1220 Identified Species: 10.77
UniProt: O15047 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15047 NP_055527.1 1707 186034 S1220 D H A S L V K S W P E E V S R
Chimpanzee Pan troglodytes XP_523492 1707 185692 S1220 D H A S L V K S W P E E V S R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848999 1330 145541 G899 W P E E V S R G G R S R A G G
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 S1425 S S P Q V P G S P F S Y P S P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506028 1287 141359 N856 P P A V L A L N V P Q P V P P
Chicken Gallus gallus Q5F3P8 2008 223067 E1382 T K T S I E E E I P R T P G R
Frog Xenopus laevis Q66J90 1938 216239 P1414 F N F T P I F P E S N S I F P
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 L1293 T P G S D T P L T G N S L S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 D1170 F E S A S K V D T T L V N I I
Honey Bee Apis mellifera XP_395451 1406 159180 R975 E E S L E I R R L R Y Q A E A
Nematode Worm Caenorhab. elegans Q18221 1507 171664 I1076 V H W E K A G I I E M N L P A
Sea Urchin Strong. purpuratus XP_791552 1963 220543 S1469 S D E D W T E S S S S S E T E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38827 1080 123894 L649 I K P M A H L L N E E T D S K
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 D882 A E D K E T E D S R L P T P I
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.2 N.A. 37 N.A. N.A. 27.7 34.5 34.1 36.7 N.A. 25.6 24.6 20.9 23.7
Protein Similarity: 100 99.5 N.A. 74.7 N.A. 49.5 N.A. N.A. 38.7 47.5 48.6 50.7 N.A. 41.3 39.6 35.8 39.2
P-Site Identity: 100 100 N.A. 0 N.A. 13.3 N.A. N.A. 26.6 20 0 13.3 N.A. 0 0 6.6 6.6
P-Site Similarity: 100 100 N.A. 13.3 N.A. 20 N.A. N.A. 40 33.3 26.6 20 N.A. 13.3 33.3 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 22.2
Protein Similarity: N.A. N.A. N.A. N.A. 33.8 36.5
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 0
P-Site Similarity: N.A. N.A. N.A. N.A. 20 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 22 8 8 15 0 0 0 0 0 0 15 0 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 15 8 8 8 8 0 0 15 0 0 0 0 8 0 0 % D
% Glu: 8 22 15 15 15 8 22 8 8 15 22 15 8 8 8 % E
% Phe: 15 0 8 0 0 0 8 0 0 8 0 0 0 8 0 % F
% Gly: 0 0 8 0 0 0 15 8 8 8 0 0 0 15 8 % G
% His: 0 22 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 8 15 0 8 15 0 0 0 8 8 15 % I
% Lys: 0 15 0 8 8 8 15 0 0 0 0 0 0 0 8 % K
% Leu: 0 0 0 8 22 0 15 15 8 0 15 0 15 0 0 % L
% Met: 0 0 0 8 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 8 0 0 0 0 0 8 8 0 15 8 8 0 0 % N
% Pro: 8 22 15 0 8 8 8 8 8 29 0 15 15 22 22 % P
% Gln: 0 0 0 8 0 0 0 0 0 0 8 8 0 0 0 % Q
% Arg: 0 0 0 0 0 0 15 8 0 22 8 8 0 0 22 % R
% Ser: 15 8 15 29 8 8 0 29 15 15 22 22 0 36 8 % S
% Thr: 15 0 8 8 0 22 0 0 15 8 0 15 8 8 0 % T
% Val: 8 0 0 8 15 15 8 0 8 0 0 8 22 0 0 % V
% Trp: 8 0 8 0 8 0 0 0 15 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 8 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _